Research Associate* - Protein Science

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Research Associate*- Protein Science

BioNTech R&D Austria is a wholly owned subsidiary of BioNTech SE, focused on the development of novel antibacterial drugs to treat persistent bacterial infections. Our development programs are based on our proprietary LysinBuilder platform, which allows the targeted development of synthetic lysins for virtually any bacterial pathogen. We use a combination of randomized directed evolution approaches and rational in-silico engineering, coupled to high-throughput screening, to generate artificial lysins and develop them into drugs. The development pipeline focuses on chronic bacterial infections where antibiotics fail to cure or destroy the natural microbiomes. Our lead asset is BNT331, which we develop for the treatment of bacterial vaginosis. We also work on transforming the standard of care with lysins against several other infections and dysbioses.

As Research Associate* at BioNTech R&D Austria you will join our research team and help us bring next generation drugs from the bench into the clinic.


Your main responsibilities are:

  • Execute series of experiments to support the developmental program, following established protocols or developing new methods, including:

    • Mammalian cell culture; cell line engineering

    • Molecular cloning

    • Expression and purification of proteins for scientific research

    • Activity testing of lysins against bacterial strains (BSL-2 strains like Gardnerella, others)

    • Directed evolution screens of enzymes

    • Biophysical and biochemical characterization of lysins

    • Isolation of bacteria from human and environmental samples

  • Actively participate in designing the required experiments and improving the established protocols, as part of the lab team

  • Develop capabilities in operating advanced equipment, including programming of a liquid handling robot, HPLC/FPLC and documenting key methods

  • Documentation of results according to the BioNTech R&D Austria Quality Standards (non-GLP), to ensure the quality of results and their documentation are acceptable to regulatory authorities, working towards a human clinical trial application

  • Establish research processes according to the latest microbiological technology developments (e.g. robotics and genomic data)

  • Maintain laboratory infrastructure together with the team, including purchasing of reagents and equipment, in-house preparation of materials like media and agar plates



What you have to offer.

  • Completed university degree (BSc. or MSc.) in biochemistry, biology, molecular biology or a related subject or vocational training as lab technician (this position is not suitable for candidates with a PhD)

  • At least 1 year of (cumulative) laboratory experience during internships or work experience

  • At least 6 months research experience in at least one of the following areas

    • Protein expression and purification in E. coli, yeasts, or other expression systems

    • Microbiological assays involving proteins (biofilms, MIC assays, enzymatic assays etc.)

    • Engineering of proteins, combinatorial methods, library screening with proteins

  • Interest in targeted pharmaceutical development

  • Interest in working in a team of highly skilled and motivated professionals

  • Fluent in English

Benefits for you. 

  • Become part of developing a new drug class in anti-infectives

  • Take responsibility for specific parts of the development program and work together with highly experienced researchers in executing the development plan

  • Pioneer new methods and processes to industrialize key research techniques

  • Be part of a highly motivated, multinational and fun team that believes synthetic lysins can be part of the solution to the global antibiotics crisis

  • A competitive compensation package that reflects the qualifications and seniority of the candidate and may include further, e.g. performance-based, incentives. Due to legal requirements, we are required to state that the minimum salary for this job is a monthly salary of EUR 2.500,-- gross.

... and much more.

Have we kindled your pioneering spirit? 

Then apply now for our location Wien and simply send us your application documents (CV, cover letter) using our online form.

If you have any further questions, our Talent Acquisition Team will be happy to answer them on + 49 (0) 6131-9084-1291 (monday-friday, from 12 noon to 4 pm).

Job-ID 2966 (please indicate for inquiries)

We look forward to your application!

*BioNTech does not differentiate on the basis of gender, political opinion, religion or belief, nationality, ethnic or social origin, age, sexual orientation, marital status, disability, physical appearance, health status or any other aspect of personal status. We are committed to creating a diverse and inclusive environment and are proud to be an equal opportunity employer. Most important – it’s a match!

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