Senior Director* Translational Sciences


Become a member of the BioNTech Family!

As a part of our team of more than 5.000 pioneers, you will play a key role in developing solutions for some of the most crucial scientific challenges of our age. Within less than a year, we were able to develop our COVID-19 mRNA vaccine following the highest scientific and ethical standards – writing medical history.
We aim to reduce the suffering of people with life-changing therapies by harnessing the potential of the immune system to develop novel therapies against cancer and infectious diseases. While doing so, we are guided by our three company values: united, innovative, passionate. Get in touch with us if you are looking to be a part of creating hope for a healthy future in many people's lives.


Senior Director* Translational Sciences 


Your main responsibilities are:


  • Based on deep knowledge of and extensive experience with oncology, you will drive the translational strategies for clinical development of programs based on an integrated view of the respective translational expert functions 
  • You will also drive reverse translation of insights based on clinical trial-derived biomarker data eg by supporting design of preclinical experiments for hypothesis-testing or mechanistic studies
  • You will work with a cross-functional team (clinical team, regulatory, diagnostics, biostatistics, preclinical) to ensure the key definitions in clinical translational steps are in agreement with clinical development and regulatory approvals

  • At the same time, you have to ensure that the translational science function is deeply embedded into the discovery and research environment in which the clinical programs are rooted and have to understand and operationalize the original scientific rationales that have led to development decisions of the individual clinical pipeline compounds

  • You are co-responsible for the strategic and scientific and budgetary planning of translational approaches in the assigned development portfolio

  • You will be responsible for the development and implementation of innovative strategies for translational approaches and deliverables for the assigned oncology portfolio. Through such strategies it enables the programs to achieve important clinical milestones, e.g. Proof of Clinical Principle

  • You will have the accountability to steer and deliver the biomarker strategy for multiple programs from exploratory early studies to phase 2/3 studies with registrational intend, in alignment with clinical development objectives (for area of accountability) for the assigned portfolio

  • You are accountable to strengthen the interfaces, processes and approaches across functions and teams within BioNTech, and strive for continuous improvement and acceleration. You are a role-model for accountability and inclusive leadership to build trustful relationship and networks across multiple functions and key stakeholders
  • You are a trusted advisor and collaboration partner for investigators outside of BioNTech and because of your reputation and experience build trustful connections to jointly enhance our clinical development pathways
  • You are accountable to manage a cohesive and engaged team of experts in Translational Science, embodie our leadership behaviors and capabilities, building safe and inclusive working culture in your teams


What you have to offer:


  • PhD with 12 to 15+ years of industry experience in oncology drug development with a track record of high impact in clinical trial supporting Translational Science and reverse translational approaches
  • Demonstrated experience in applying translational and innovative biomarker strategies to both preclinical and clinical development portfolios
  • Demonstrated experience in contextualizing biomarker data in understanding pharmacodynamics and mode of action of therapies and in definition of patient populations
  • In depth understanding of translational medicine and biomarker mechanisms associated with immune-oncology and targeted therapies
  • Successful track record leading translational activities for multiple clinical programs, including programs in early-, mid-, and late-stage development
  • Extensive insight and experience in basic, translational and clinical research related to biomarkers, pharmacogenetics, imaging, and digital pathology
  • Leadership and management experience

  • Strong understanding of technical, regulatory, clinical, and strategic aspects of biomarker assessments in clinical development

  • Ability to independently drive, manage, execute, and deliver results for a portfolio of complex multi-functional projects

  • Collaborate and strategize across the entire Oncology organization to improve efficiency and accelerate the product pipeline forward

Benefits for you:

  • Flexible Working Time
  • Mobile Office
  • Work from EU Countries
  • Company Pension Scheme
  • Childcare
  • Jobticket
  • Company Bike
  • Leave Account
  • Fitness Courses

... and much more.


Have we kindled your pioneering spirit? 


Then apply now for our location Mainz Goldgrube and simply send us your application documents using our online form.

If you have any further questions, our Talent Acquisition Team will be happy to answer them on + 49 (0) 6131-9084-1291 (monday-friday, from 12 noon to 4 pm).

Job-ID 5526 (please indicate for inquiries)

We look forward to your application!

*BioNTech does not tolerate discrimination, favoritism, or harassment based on gender, political opinion, religion or belief, nationality, ethnic or social origin, age, sexual orientation, marital status, disability, physical appearance, health status or any other aspect of personal status. We are committed to creating a diverse and inclusive environment and are proud to be an equal opportunity employer. Most important – it’s a match!

BioNTech - As unique as you