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Senior Scientist II, Group Lead

 

Join our team of pioneers!

Based in Cambridge, MA and Gaithersburg, MD. We are committed to improving the health of people worldwide with our fundamental research and our work in the area of development of immunotherapies utilizing the full potential of the immune system to fight cancer, infectious diseases and other serious diseases. We believe in scientific rigor, innovation and passion as driving forces. BioNTech was founded by scientists and physicians to translate science into survival by combining fundamental research and operational excellence.

With decades of deep immunology expertise and experience in developing and optimizing mRNA as part of its broad suite of novel technologies, the company is working with the global community to defeat life-threatening and serious diseases such as cancer, COVID-19, malaria and tuberculosis. The first ever approved mRNA vaccine was created in the labs of BioNTech in Mainz, Germany. A fully integrated immunotherapy powerhouse. We remain focused on bringing our broad pipeline of next-generation immunotherapies and vaccines to people around the world to address cancer, infectious diseases, as well as a growing list of other medical conditions. To accomplish this, we continue to be deeply rooted in science and academic research while also having built a fully integrated, global immunotherapy company with cGMP and GMP manufacturing facilities anchored around deep expertise in immunology and complemented by an expanding set of capabilities.
 

 

Senior Scientist II, Group Lead

 

Position Summary

BioNTech US is seeking a creative, passionate, and curious Group Leader to join the Proteomics group and lead a team focused on advanced mass spectrometry-based applications for translational research. The successful candidate will work independently and as a strategic contributor on cross-functional teams to help pioneer and establish new technologies and workflows to advance preclinical validation of individualized cancer vaccines for oncology (IVAC) and vaccine development for infectious disease programs. Furthermore, the successful candidate will apply proteomics methodologies to support other therapeutic modalities such as antibody drug conjugates (ADCs). Leading a team as part of the Proteomics unit at BioNTech US, the successful candidate will interact with a cross functional group of scientists with the goal of establishing and applying advanced Proteomics workflows for exciting, translational research.

 

Primary Responsibilities

  • Lead a team in Proteomics sample processing techniques for nanoLC-MS/MS analysis, including enzymatic digestion, desalting, chemical modification, and fractionation
  • Collaborate and strategize with scientists across cross-functional teams to appropriately apply MS-based proteomics for preclinical validation across portfolios within BioNTech
  • Lead a team in the optimization and execution of immunopurification and other affinity-based enrichment strategies
  • Oversee generation of biological samples via mammalian cell culture
  • Method development and implementation of protein purification strategies for isolation of membrane and intracellular proteins from cells and tissues
  • Contributions to nanoLC-MS/MS experimental design
  • Review of scientific literature and collaboration with cross-functional teams
  • Tracking and compiling of results in an electronic notebook
  • Assisting with training of lab personnel
  • Analysis and presentation of results to cross-functional teams


Requirements: 

  • PhD degree in proteomics, biology, chemistry or relevant field; 8+ years of relevant research experience in academia or industry; at least 1 year of working experience in the pharmaceutical or biotechnology industries
  • Background in cell biology, biochemistry, molecular biology, biotechnology and immunology
  • Expert knowledge of proteomic workflows for sample processing (enzymatic digestion of proteins, chemical modification, desalting, fractionation, isobaric tag labeling, etc.) and for data acquisition with nanoLC-MS/MS including unbiased (DDA, DIA) and targeted (PRM, SQ) data collection and MS-based quantitative assays
  • Hands on experience with biological mass spectrometry including orbitraps, timsTOF and expert knowledge of MS search algorithms for data analysis
  • Experience and proficiency with a broad range of MS acquisition methods, including DDA, DIA, and advanced targeted approaches.
  • Demonstrated success as an effective independent scientist and scientific team leader
  • Strong written and oral communication skills
  • Ability to critically evaluate data and offer strategic input on timelines/future direction

 

Preferred Requirements:

  • Strong understanding of human immunology is a plus
  • Experience with R, python, or other coding software
  • Experience with mammalian cell culture, including transfection and lentiviral transduction, and comfort with optimizing cell culture protocols
  • Experience with management and training colleagues on proteomics workflows
  • Ability to maintain inventories of equipment, supplies, and related research materials
  • Ability to read and digest information from the scientific literature and teach others learned concepts.
  • Excellent organizational, communication skills, and attention to detail



Benefits for you:
 

BioNTech US is committed to employee wellbeing and offers best-in-class benefits & HR programs to support an inclusive & diverse workforce. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:

  • Medical, Dental and Vision Insurance

  • Life, AD&D, Critical Illness Insurance

  • Pre-tax HSA & FSA, DCRA Spending Accounts

  • Employee Assistance & Concierge Program (EAP) available 24/7

  • Parental and Childbirth Leave & Family Planning Assistance

  • Sitterstream: Virtual Tutoring & Childcare Membership

  • Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.

  • 401(K) Plan with Company Match

  • Tuition Reimbursement & Student Loan Assistance Programs

  • Wellbeing Incentive Platforms & Incentives

  • Professional Development Programs

  • Commuting Allowance and subsidized parking

  • Discounted Home, Auto & Pet Insurance

 

…and more! More details to be shared.


 

BioNTech is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. BioNTech does not tolerate discrimination against employees or applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex (including gender, pregnancy, sexual orientation, and gender identity), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, genetic information, or any other characteristic protected under applicable federal, state, or local law.

If you are unable or limited in your ability to use or access BioNTech’s online application tools due to a disability, you can request reasonable accommodations by calling 1-857-228-6231or by e-mailing jobs@biontech.de. Thank you for your interest in BioNTech.

 

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