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Senior Scientist, Synthetic Chemist

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Based in Cambridge, MA and Gaithersburg, MD. We are committed to improving the health of people worldwide with our fundamental research and our work in the area of development of immunotherapies utilizing the full potential of the immune system to fight cancer, infectious diseases and other serious diseases. We believe in scientific rigor, innovation and passion as driving forces. BioNTech was founded by scientists and physicians to translate science into survival by combining fundamental research and operational excellence.

With decades of deep immunology expertise and experience in developing and optimizing mRNA as part of its broad suite of novel technologies, the company is working with the global community to defeat life-threatening and serious diseases such as cancer, COVID-19, malaria and tuberculosis. The first ever approved mRNA vaccine was created in the labs of BioNTech in Mainz, Germany. A fully integrated immunotherapy powerhouse. We remain focused on bringing our broad pipeline of next-generation immunotherapies and vaccines to people around the world to address cancer, infectious diseases, as well as a growing list of other medical conditions. To accomplish this, we continue to be deeply rooted in science and academic research while also having built a fully integrated, global immunotherapy company with cGMP and GMP manufacturing facilities anchored around deep expertise in immunology and complemented by an expanding set of capabilities.
 

 

Senior Scientist, Synthetic Chemist

 

Position Summary

BioNTech is developing novel Antibody-Drug Conjugates (ADCs) and other targeted therapeutics for the targeted treatment of cancer with the goal of maximizing efficacy and minimizing toxic effects to future patients.  To achieve this goal ADCs will be prepared, evaluated in a battery of in vitro and in vivo assays, then, based on results, improved conjugates will be developed.

 

As a Chemistry Senior Scientist in the ADC Innovation Unit, you will help design and synthesize the payloads, linkers and linker-payloads required to prepare ADCs.  You may also be involved in the conjugation step, attaching linker-payloads to antibodies.  You will work closely with team members who have diverse backgrounds in Biology, Pharmacology and other disciplines.  You will also prepare presentations for the team, and possibly for upper management, that include progress updates and proposals for linker-payload improvements.

 

Primary Responsibilities

  • Work with a team designing and producing ADCs and other targeted therapeutics
  • Design, synthesize, and purify small molecules, peptides, potent payloads, and potentially conjugate them to proteins.
  • Work in a safe manner, using appropriate containment for potent compounds.
  • Use NMR and HPLC/UPLC techniques to prove the identity and purity of prepared compounds
  • Prepare presentations and work cross-functionally within the organization in various areas including formulation, drug delivery, pharmacokinetics, and pharmacodynamics
  • Liaise with BioNTech partners, CROs and CDMOs


Requirements:

  • Ph.D. in synthetic organic chemistry, or a related discipline with 3+ years of industry experience in drug discovery and development
  • Hands-on experience preparing complex organic molecules and using HPLC, LC-MS and NMR for purification/analysis
  • Proven track record of creative thinking and consistent delivery as demonstrated by publications and presentations
  • Excellent interpersonal, networking, and communication skills
  • Must be able to work on-site

 

Desirable Skills:

  • Experience in medicinal chemistry
  • Experience in ADC chemistry



Benefits for you:
 

BioNTech US is committed to employee wellbeing and offers best-in-class benefits & HR programs to support an inclusive & diverse workforce. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:

  • Medical, Dental and Vision Insurance

  • Life, AD&D, Critical Illness Insurance

  • Pre-tax HSA & FSA, DCRA Spending Accounts

  • Employee Assistance & Concierge Program (EAP) available 24/7

  • Parental and Childbirth Leave & Family Planning Assistance

  • Sitterstream: Virtual Tutoring & Childcare Membership

  • Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.

  • 401(K) Plan with Company Match

  • Tuition Reimbursement & Student Loan Assistance Programs

  • Wellbeing Incentive Platforms & Incentives

  • Professional Development Programs

  • Commuting Allowance and subsidized parking

  • Discounted Home, Auto & Pet Insurance

 

…and more! More details to be shared.


 

BioNTech is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. BioNTech does not tolerate discrimination against employees or applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex (including gender, pregnancy, sexual orientation, and gender identity), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, genetic information, or any other characteristic protected under applicable federal, state, or local law.

If you are unable or limited in your ability to use or access BioNTech’s online application tools due to a disability, you can request reasonable accommodations by calling 1-857-228-6231or by e-mailing jobs@biontech.de. Thank you for your interest in BioNTech.

 

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