Scientist, Systems Immunology

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Based in Cambridge, MA and Gaithersburg, MD. We are committed to improving the health of people worldwide with our fundamental research and our work in the area of development of immunotherapies utilizing the full potential of the immune system to fight cancer, infectious diseases and other serious diseases. We believe in scientific rigor, innovation and passion as driving forces. BioNTech was founded by scientists and physicians to translate science into survival by combining fundamental research and operational excellence.

With decades of deep immunology expertise and experience in developing and optimizing mRNA as part of its broad suite of novel technologies, the company is working with the global community to defeat life-threatening and serious diseases such as cancer, COVID-19, malaria and tuberculosis. The first ever approved mRNA vaccine was created in the labs of BioNTech in Mainz, Germany. A fully integrated immunotherapy powerhouse. We remain focused on bringing our broad pipeline of next-generation immunotherapies and vaccines to people around the world to address cancer, infectious diseases, as well as a growing list of other medical conditions. To accomplish this, we continue to be deeply rooted in science and academic research while also having built a fully integrated, global immunotherapy company with cGMP and GMP manufacturing facilities anchored around deep expertise in immunology and complemented by an expanding set of capabilities.


Scientist, Systems Immunology


Job summary

BioNTech US is seeking a highly motivated vaccinologist to join the Systems Immunology team. Our group aims to first understand immune responses from a big-picture perspective and then harness these responses to derive novel tools to combat infectious diseases. The successful candidate will work within a dynamic, collaborative, and multidisciplinary environment consisting of computational biologists, structural biologists, immunologists, and microbiologists on the Systems Immunology team and within the broader BioNTech research community. Key responsibilities of this role are to design and execute large-scale and diverse immunoassays to help evaluate leading vaccine candidates including BioNTech’s cutting edge malaria and mpox vaccines. This role also offers the opportunity to contribute to design and characterization of early-stage vaccine candidates. If you are excited about infectious diseases vaccines and having project ownership while working on a highly collaborative team to achieve mutual goals, this will be a good fit for you.


Primary responsibilities include:

  • Develop and perform immunological assays, including ELISAs, ELISpots, flow cytometry, and fluorescence activated cell sorting, with a special focus on development of high-throughput measures of antibody function.
  • Drive early-stage evaluation of novel vaccine designs.  
  • Collaborate and communicate experimental progress with both internal research teams and external groups to advance team projects.
  • Maintain a high standard of record keeping and experimentation, including assay and instrument troubleshooting.
  • Contribute to IND-enabling studies and technical document writing for filing.
  • Work productively in a team environment and independently to deliver against timelines.



  • PhD in Immunology, Virology, Microbiology or related field with in-depth knowledge of host-pathogen interactions.
  • Experience in humoral immunology in infectious disease, immunogen design, or related discipline is preferable.
  • Virology expertise is highly desired.
  • Demonstrated experience in cell-based immunoassays, ELISAs, ELISpots, multi-color flow cytometry and fluorescence activated cell sorting is highly desired.
  • Strong attention to detail and the ability to work cross-functionally.
  • Excellent written and oral communication skills
  • Enjoys solving challenging scientific questions in a fast-paced environment.

Benefits for you:

BioNTech US is committed to employee wellbeing and offers best-in-class benefits & HR programs to support an inclusive & diverse workforce. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:

  • Medical, Dental and Vision Insurance

  • Life, AD&D, Critical Illness Insurance

  • Pre-tax HSA & FSA, DCRA Spending Accounts

  • Employee Assistance & Concierge Program (EAP) available 24/7

  • Parental and Childbirth Leave & Family Planning Assistance

  • Sitterstream: Virtual Tutoring & Childcare Membership

  • Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.

  • 401(K) Plan with Company Match

  • Tuition Reimbursement & Student Loan Assistance Programs

  • Wellbeing Incentive Platforms & Incentives

  • Professional Development Programs

  • Commuting Allowance and subsidized parking

  • Discounted Home, Auto & Pet Insurance


…and more! More details to be shared.


BioNTech is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. BioNTech does not tolerate discrimination against employees or applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex (including gender, pregnancy, sexual orientation, and gender identity), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, genetic information, or any other characteristic protected under applicable federal, state, or local law.

If you are unable or limited in your ability to use or access BioNTech’s online application tools due to a disability, you can request reasonable accommodations by calling 1-857-228-6231or by e-mailing Thank you for your interest in BioNTech.