(Senior) Scientist, T-Cell Immunology

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Based in Cambridge, MA and Gaithersburg, MD. We are committed to improving the health of people worldwide with our fundamental research and our work in the area of development of immunotherapies utilizing the full potential of the immune system to fight cancer, infectious diseases and other serious diseases. We believe in scientific rigor, innovation and passion as driving forces. BioNTech was founded by scientists and physicians to translate science into survival by combining fundamental research and operational excellence.

With decades of deep immunology expertise and experience in developing and optimizing mRNA as part of its broad suite of novel technologies, the company is working with the global community to defeat life-threatening and serious diseases such as cancer, COVID-19, malaria and tuberculosis. The first ever approved mRNA vaccine was created in the labs of BioNTech in Mainz, Germany. A fully integrated immunotherapy powerhouse. We remain focused on bringing our broad pipeline of next-generation immunotherapies and vaccines to people around the world to address cancer, infectious diseases, as well as a growing list of other medical conditions. To accomplish this, we continue to be deeply rooted in science and academic research while also having built a fully integrated, global immunotherapy company with cGMP and GMP manufacturing facilities anchored around deep expertise in immunology and complemented by an expanding set of capabilities.


(Senior) Scientist, T-Cell Immunology


Position Description:
BioNTech is seeking a highly-motivated Scientist to work as part of a multi-disciplinary team developing neoantigen specific T cell products to be used in adoptive T cell therapy. You will work closely with the Cell Therapy Unit, Bioinformatics, Translational Immunology, Translational sciences, and CMC and Technical Operations to develop and validate characterization assays and analytical methods. You will apply these to understand the characteristics and 
the quality of the cell therapy drug product. This position reports to Group leader-DPCAD/T cell Immunology leading the cross functional Drug Product Characterization and Analytical Development team. 


Primary responsibilities include:

  • Lead and develop strategy to execute and understand T cell characteristics of drug product for phase 1 clinical trials of personalized autologous, neoantigen-specific T cell therapies.
  • Design, develop and document new assays for the product characterization.
  • Assessment of specificity and functionality of human T cells by multicolor flow cytometry
  • Perform single cell sequencing of antigen specific cells using 10X platform.
  • Collaborate with cross functional teams to strategize, analyze and curate the data collected.
  • Tracking and compiling results in an electronic notebook
  • Present results to both scientific and cross-functional teams
  • Train and support junior associates on the team to broadly move the project forward.


What you have to offer:

  • Ph.D. in T cell immunology or related discipline with 2+ years of relevant industry experience, eg translational immunology and/or immune monitoring and strong knowledge of T cell biology and/or immuno-oncology
  • Demonstrated proficiency in primary cell culture, flow cytometry and other immune related assays such as co-culture assays, single cell sequencing, cytotoxicity assays etc., is required.
  • Experience in conducting immune analysis and demonstrating an understanding of T cell functionality and phenotype in clinical settings is strongly preferred.
  • Excellent attention to detail with ability to work independently in a collaborative environment to achieve project goals.
  • Excellent written and oral communication skills
  • Flexible, self-motivated and thrives in a fast-paced environment where challenging scientific questions are tackled with enthusiasm.

Benefits for you:

BioNTech US is committed to the well being of our team members and offers a variety of benefits supporting our diverse employee base. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:

  • Medical, Dental and Vision Insurance

  • Life, AD&D, STD and LTD Insurance

  • HSA & FSA Spending Accounts

  • Health & Wellness, including free onsite gym access

  • Adoption & Surrogacy Assistance

  • Vacation and Unlimited Sick Time

  • Holidays and Floating Holidays, including discretionary winter shutdown

  • 401(K) Plan with Significant Company Match

  • Tuition Reimbursement and Professional Development

  • Commuting Assistance and subsidized parking

  • Discounted Home and Auto Insurance

  • Pet Insurance

Plus more benefits that will be shared upon hire!


Have we kindled your pioneering spirit? 

Then apply now for our location Cambridge (Boston) and simply send us your application documents using our online form.

BioNTech does not tolerate discrimination, favoritism, or harassment based on gender, political opinion, religion or belief, nationality, ethnic or social origin, age, sexual orientation, marital status, disability, physical appearance, health status or any other aspect of personal status. We are committed to creating a diverse and inclusive environment and are proud to be an equal opportunity employer. Most important – it’s a match!

BioNTech - As unique as you